Cardiac patients uninformed about
dangerous food and drug interactions
MONTREAL, Oct. 25 /CNW Telbec/ - Cardiac medications mixed
with certain foods and herbal supplements can endanger
patients' health, especially in those taking multiple
medications.
A paper
by Nancy Chaytor presented today at the Canadian
Cardiovascular Congress 2005, co-hosted by the Heart and
Stroke Foundation of Canada and the Canadian
Cardiovascular Society, says there is a knowledge deficit
in this area. Her presentation described many known
food-drug interactions which clinicians should, but don't
always, discuss with patients.
"It is
vital that people taking cardiac medications are aware of
these potentially dangerous interactions, and that they
tell their doctor everything they are taking" says Dr.
Beth Abramson, Heart and Stoke Foundation spokesperson.
"Through my own research on complementary and alternative
medicines I know that sharing that information is
critical, but often doesn't
happen."
"The
way the body metabolizes medications and foods can result
in a drug being either less effective or too potent - and
this can have life or death consequences," says Chaytor, a
nurse practitioner in medical cardiology with the Calgary
Health Region who prescribes medications. A drug's potency
can be affected by many factors including genetics, age,
gender, disease states, diet, or social factors. A single
glass of grapefruit juice can increase or,less commonly,
decrease the level of a drug in your blood.
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Some potentially dangerous interactions include
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Medication
Food/herbal product
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Medications for high blood pressure
Grapefruit and grapefruit juice
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Medications for irregular heart
Grapefruit and grapefruit juice
rhythms
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Monoamine Oxidase (MAO)
Foods high in tyramine (such
inhibitors
as beer, wine, certain cheeses,
and sausages)
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Warfarin (an anticoagulant)
Grapefruit and grapefruit juice
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Warfarin
Food with vitamin K (such as
liver, broccoli, Brussel sprouts,
green leafy vegetables)
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Warfarin
Ginkgo biloba
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Warfarin
Ginseng
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Anticoagulants (blood thinners)
Papaya extract
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Anticoagulants (blood thinners)
Devil's claw
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Anticoagulants (blood thinners)
Smoking cigarettes
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>>
For example, smokers on anticoagulant medications may not
think to tell their physician they are cutting down or
quitting. But smoking makes these medications less
effective, so physicians prescribe smokers an increased
dosage. If a patient quits, the dose will be too high -
potentially putting the patient's health at risk.
Herbal
preparations, like such as garlic supplements, may seem
harmless but they may interact with blood pressure or
anticoagulant medications. That is why it is important to
always tell your doctor or healthcare provider about all
supplements you are taking.
Chaytor
looked at the CYP450 system - a group of proteins found
mostly in the part of the liver where metabolism takes
place. These proteins can be directly affected by the
consumption of certain foods and herbal remedies and can
either increase or decrease the effectiveness of a drug.
"It's
important that clinicians are well-informed about these
interactions and educate their patients," says Chaytor.
The Heart and Stroke Foundation ( www.heartandstroke.ca )
is a leading funder of heart and stroke research in
Canada. The Foundation's mission is to improve the health
of Canadians by preventing and reducing disability and
death from heart disease and stroke through research,
health promotion and advocacy.