chemical's ability to fight cancer put to the test
6 May 2012
an ingredient in curry have a role in cancer
A chemical found in curry is to be tested for its
ability to kill bowel cancer tumours in patients.
Curcumin, which is found in the spice turmeric, has
been linked to a range of health benefits.
Studies have already shown that it can beat cancer
cells grown in a laboratory and benefits have been
suggested in stroke and dementia patients as well.
Now a trial at hospitals in Leicester will be
investigating giving curcumin alongside chemotherapy
About 40,000 people are diagnosed with bowel cancer
in the UK each year.
If the disease spreads around the body, patients are
normally given a combination of three chemotherapy
drugs, but about half will not respond.
Forty patients at Leicester Royal Infirmary and
Leicester General Hospital will take part in the
trial, which will compare the effects of giving
curcumin pills seven days before starting standard
'Difficult to treat'
Prof William Steward, from Leicester University, who
is leading the study, said animal tests combining
the two were "100 times better" than either on their
own and that had been the "major justification for
cracking on" with the trial.
He said: "Once bowel cancer has spread it is very
difficult to treat, partly because the side effects
of chemotherapy can limit how long patients can have
"The prospect that curcumin might increase the
sensitivity of cancer cells to chemotherapy is
exciting because it could mean giving lower doses,
so patients have fewer side effects and can keep
having treatment for longer.
"This research is at a very early stage, but
investigating the potential of plant chemicals to
treat cancer is an intriguing area that we hope
could provide clues to developing new drugs in the
Joanna Reynolds, from Cancer Research UK, said: "By
doing a clinical trial like this, we will find out
more about the potential benefits of taking large
amounts of curcumin, as well as any possible side
effects this could have for cancer patients."
prepared, spring is in the air: CSA Group seasonal
safety tips for all your long weekends and the days
Toronto, May 15, 2012 /CNW/ -
Spring and summer
bring warmth and sunshine to the winter-wearied and
renew our passion for the great outdoors. From
camping to leisurely summer getaways, being outside
and enjoying the tremendous weather with friends and
family is a valued national past-time that many
people embrace at every opportunity.
CSA Group, a leading certification and testing
organization, wants to help everyone to stay and
play safe during the coming long weekends and all
season long by offering the following safety tips:
Whenever cooking outdoors, a few basic safety tips
Gas Grills and Barbecues
Make a clean start.
Before firing up the grill for the first time
this season, carefully inspect burners and
burner tubes for blockages due to dirt, grease,
insects or rust build-up. Clean or replace any
blocked parts or have a certified technician
To make sure there are no gas leaks, rub a 50/50
solution of soap and water onto the gas hose,
fittings and connections and turn the gas on at
the tank but not the burners. Any leaks will
produce bubbles. Tighten the fittings if
required and replace any damaged hoses or
Take a pass on old gas!
Propane cylinders must be inspected and
requalified every 10 years in Canada and 12
years in the US. A date stamp on the cylinder
indicates when it was last qualified. Do not use
a rusty or damaged cylinder. If in doubt, have
your tank replaced.
Keep grills and barbecues away from combustible
materials such as fences, trees, buildings,
awnings and carports. Never use a barbecue in a
Buy the Certification
Flame. When purchasing or installing
a gas barbecue, make sure that it carries the
mark of an accredited certification agency such
as the CSA Group Certification Flame or Star
Mark indicating that it meets applicable
Camping And Boating
Visiting a camp site, cottage or lake? Remember
these tips for a safer summer expedition.
Camping Stoves and
Three meters from the
tent. Fuel-burning camping equipment
such as stoves, lanterns and outdoor cookers
should only be lighted outdoors and at least
three meters from tents, combustible materials
and vehicles. Never light a stove or lantern
indoors or in a tent or vehicle. Before use,
carefully inspect parts for leaks, blockages or
Free the flame.
To prevent carbon monoxide poisoning,
fuel-burning equipment should only be used in
Hot is not cool.
Keep loose, flammable clothing away from
open flames and carefully monitor children and
pets around stoves and lanterns. Before packing
up equipment, make sure it is completely turned
off and cool to the touch.
Boats and Cottages
Always wear a personal flotation device and
never consume alcohol or intoxicants while
operating a vehicle.
Ensure that certified carbon monoxide and smoke
alarms are tested and properly installed outside
all sleeping areas of your cabin, cottage or
When opening your cabin, cottage or rustic
retreat for the season, carefully inspect all
appliances for damage from rodents or insects.
Ensure boats and cottages are equipped with
proper safety equipment in the event of an
emergency, including first aid kits and fire
more everyday consumer tips and safety advice,
Scientists hunt ways to stall Alzheimer's earlier
By Lauran Neergaard | Associated Press
Washington (AP) —
Look for a fundamental shift in how scientists hunt
ways to ward off the devastation of Alzheimer's
disease — by testing possible therapies in people
who don't yet show many symptoms, before too much of
the brain is destroyed.
The most ambitious attempt: An international study
announced Tuesday will track whether an experimental
drug can stall the disease in people who appear
healthy but are genetically destined to get a type
of Alzheimer's that runs in the family. If so, it
would be exciting evidence that maybe regular
Alzheimer's is preventable too.
A second study will test whether a nasal spray that
sends insulin to the brain helps people with very
early memory problems, based on separate research
linking diabetes to an increased risk of
The new focus emerges as the Obama administration
adopts the first national strategy to fight the
worsening Alzheimer's epidemic — a plan that sets
the clock ticking toward finally having effective
treatments by 2025.
"We are at an exceptional moment," with more
important discoveries about Alzheimer's in the last
few months than in recent years, Dr. Francis
Collins, director of the National Institutes of
Health, declared Tuesday.
But a meeting of the world's top Alzheimer's
scientists this week made clear that meeting the
2025 deadline will require developing a mix of
treatments to attack the different ways that
Alzheimer's damages the brain — much like it can
take a cocktail of drugs to treat high blood
pressure or the AIDS virus.
Perhaps more importantly, it will require testing
possible drugs before full-blown Alzheimer's sets
in, when it may be too late to do much good. After
all, Alzheimer's starts ravaging the brain at least
a decade before memory problems appear. And doctors
don't wait until the worst symptoms appear before
treating heart disease, cancer or diabetes, noted
Dr. Reisa Sperling of Harvard Medical School.
"Once the train leaves the station of degeneration,
it might be too late to stop it," Sperling said. "We
need to define the critical window for
Future therapy is far from the only goal of the
first National Alzheimer's Plan. It's a two-pronged
approach, promising to provide better and support
for overwhelmed families along the way.
"A lot more needs to be done and it needs to be done
right now, because people with Alzheimer's disease
and their loved ones and caregivers need help right
now," Health and Human Services Secretary Kathleen
Sebelius said in announcing the plan.
Among the first steps: A new website —
www.alzheimers.gov — that Sebelius called a one-stop
shop for families offers easy-to-understand
information about dementia and links to resources in
their own communities. The government will offer
free training to doctors and other health providers
on how to spot the early signs of Alzheimer's and
care for those patients. This summer, a campaign
will begin to improve public awareness of
Alzheimer's, important in reducing the stigma that
helps fuel late diagnosis and the isolation that so
many affected families feel.
Patient advocates applauded the move, and country
music legend Glen Campbell, who has Alzheimer's,
appeared on Capitol Hill to urge more research.
Alzheimer's "has been in the shadows for far too
long," said Eric J. Hall of the Alzheimer's
Foundation of America. The plan "provides solid
stepping stones toward substantial change."
Already, 5.4 million Americans have Alzheimer's or
related dementias. Barring a research breakthrough,
those numbers will jump by 2050, when up to 16
million Americans are projected to have Alzheimer's.
There is no cure, and the five medications available
today only temporarily ease some symptoms. Finding
better ones has been a disappointing slog: Over the
last decade, 10 drugs that initially seemed
promising failed in late-stage testing, Sperling
Moreover, scientists still don't know exactly what
causes Alzheimer's. The chief suspects are a sticky
gunk called beta-amyloid, which makes up the
disease's hallmark brain plaques, and tangles of a
protein named tau that clogs dying brain cells. One
theory: Amyloid may kick off the disease while tau
speeds up the brain destruction.
Previous studies of anti-amyloid drugs have failed,
but that new international study will test a
different one, in a different way: About 300 people
from a huge extended family in Colombia who share a
gene mutation that triggers Alzheimer's in their 40s
will test an experimental drug, Genentech's
crenezumab, to see if it delays onset of symptoms.
The study also will include some Americans who
inherit Alzheimer's causing gene mutations.
Meanwhile, there are brain-protective steps that
anyone can take that just might help, Dr. Carl
Cotman of the University of California, Irvine, told
Tuesday's NIH meeting.
"It's just a well-kept secret," he said.
--Your brain is like a muscle so exercise it.
Intellectual and social stimulation help build
what's called "cognitive reserve," the ability to
withstand declines from aging and dementia.
—Getting physical is crucial also. Clogged arteries
slow blood flow to the brain, and people who are
less active in middle age are at increased risk of
Alzheimer's when they're older. "Any time your heart
is healthier, your brain is healthier," said Dr.
Elizabeth Head of the University of Kentucky.
--Don't forget diet, she added. The same foods that
are heart-healthy are brain-healthy, such as the
omega-3 fatty acids found in fish.
has warnings for garage salers
Just in time for summer, product safety officers
with Health Canada are warning second-hand store
owners and garage salers about safety regulations.
They're also instructing border and customs agents
about US products that don't meet Canadian safety
Click here to read more
finds poor diet remains recipe for disaster as
Canadians get older
Study lead researcher Daniel Munro said the board
came to its conclusions by analyzing statistical
data on food choices compiled over the past 20 to 30
years by agencies such as Statistics Canada and
Health Canada. Analyzing those trends, Munro said,
Click here to read more
injuries can be prevented
Toronto, May 15, 2012 /CNW/ -
A recent CNIB survey -
released as part of Vision Health Month - revealed
that each year an estimated 720,000 Canadians
sustain an eye injury that requires medical
"Many people think eye injuries only happen in
industrial settings - where machines or chemicals
are involved," said Dr. Keith Gordon, CNIB's
Vice-President of Research. "But in reality, over
two thirds of eye injuries occur outside of a work
Eye injuries are some of the most frequently treated
accidents in hospital emergency rooms. CNIB's study
also estimated that about 100,000 people each year
lose time off work as a result of an eye injury.
"Eye injuries can cause serious vision loss or even
blindness, but most can be prevented," added Dr.
Gordon. "People really need to think about
protecting their eyes better not only at work, but
also at home and while playing sports."
Eye injuries that cause permanent vision loss impact
not only the person affected but their family and
Canadians can do their part to minimize the
significant social and personal costs associated
with eye injuries by taking simple steps to protect
their eyes at home, at work and at play. In addition
to always wearing sunglasses, protective goggles or
other eyewear, Canadians can follow the tips below
to help protect their eyes from common hazards.
Read and follow instructions when using
Point spray nozzles away from you
Use grease shields on frying pans
Turn your face away when uncorking soda or
champagne style bottles
Pick up rocks and stones before mowing the lawn
Trim low-hanging branches on trees in your yard
Teach children how to safely handle knives,
scissors and pencils
Keep harsh chemicals, spray cans and glues out
of a child's reach
Select toys and games suitable for a child's age
Avoid toys that could be used as projectiles,
such as darts, pellet guns and arrows
Only allow certified professionals to handle
learn more about eye safety and injury prevention,
Why young people can’t get the
jobs they want and the education they need
Martin Allen and Patrick Ainley
Already referred to as a „Lost Generation, after
almost two years of Coalition government, young
people now have even less to look forward to and are
likely to end up worse off than their parents. This
publication builds on, develops and updates
arguments from our book Lost Generation? New
strategies for youth and education (2010) and, in
particular, those in our recent e-pamphlet Why young
people can’t get the jobs they want (2011)
Voice designed and compiled by
Demerg Systems India,
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